Volume 11 - Volume 11
Mapping Scientific and Technological Production Related to the MYC Gene
Abstract
In appropriate activation of c-MYC proto-oncogene contributes to the development of human
cancers. Searches for therapies that target genes and proteins related to neoplastic phenotypes have
become frequent. Therefore, inhibiting c-MYC expression has been the target for developing and
testing multiple drugs and strategies for the treatment of various human cancers. This study aimed to
map scientific and technological productions on the MYC gene at the Scielo, PubMed and Orbit
Intelligence platforms between 2000 and 2019. The scientific prospecting revealed 1,259 articles. The
most detected categories were: molecular biology, MYC mutations and those addressing the MYC as
a drug target or therapeutic strategies. A progressive increase in the number of articles in this last
category was found. Technological mapping detected 10,059 patent documents, with 20.2% granted.
China and the USA were the largest filers, accounting for more than 40%. Biotechnology was the
field with the highest number of patents. Biotechnology and the pharmaceutical sector predominated
in the second half of the period investigated, both in scientific and technological prospecting. Our
study points to a scientific and technological effort in the development of therapeutic strategies
against cancer, in which MYC is among the main targets.
Paper Details
PaperID: 2647
Author's Name: Fabio Pacheco Estumano Da Silva, Amanda Ramos Pereira, Adan Rodrigues De Oliveira and Carlos Alberto Machado Da Rocha
Volume: Volume 11
Issues: Volume 11
Keywords: Scientific Prospecting, Technological Prospecting, MYC Gene, Cancer, Therapeutic Target.
Year: 2021
Month: December
Pages: 5897-5908