Volume 11 - Volume 11
isk Factors in Progressive Arterial Hypertension (Systemic Analysis)
Abstract
The present research aimed to access the significance of arterial hypertension risk factors and their
relationships in the high-mountain villages of the Elbrus region (2100–3500 m above the sea level).
For this, 260 patients were examined in total, 190 with arterial hypertension (hereinafter AH) of the
1, 2 and 3 degrees and 70 healthy individuals.
Methods. All the participants underwent complex examination: echocardiography; assessment of
nitric oxide (NO) metabolites in the blood; heart rate variability (HRV); blood plasma lipid spectrum.
Microsoft Statistica v. 10.0.1 software package was used for statistical processing. Multiple
regression equations reflected the dynamics of relationships of three or more parameters (significant
differences at p <0.05). Results. AH patients showed a progressive decrease in NO, an increase in sympathetic and HRV
indicators, in left ventricular (LV) myocardial mass and atherogenic plasma index. The dependence
of HRV indicators, LV morphofunctional parameters, hemodynamics, plasma lipid profile on NO
level was revealed.
Decreased significance of modifiable risk factors and increased lesions of ‘target organs’ with the
progression of arterial hypertension were found; this explains complexity of prevention and possible
therapeutic strategies.
Paper Details
PaperID: 2418
Author's Name: Maryam H. Kurdanova, Ilyas A. Beslaneev, Madina H. Kurdanova, Luisa M. Batyrbekova and Husein A. Kurdanov
Volume: Volume 11
Issues: Volume 11
Keywords: Arterial Hypertension, Risk Factors, Endothelial Dysfunction, Hemodynamics; Highlands.
Year: 2021
Month: July
Pages: 3944-3954