Volume 12 - Volume 12
A comparative study of rocuronium over suxamethonium for intubation conditions in elective surgeries in age between 18 to 65 years
Abstract
Background: Suxamethonium has two important characteristics-it produces intense paralysis rapidly and its effects are likely to wane before pre-oxygenated patient get hypoxic. It has rapid onset and a shorter duration of action (3 to 5 minutes). It makes this drug a useful drug for good skeletal muscle relaxation to facilitate tracheal intubation but simultaneously it isassociated with adverse effects that limit or contraindicate its use in certain cases
OBJECTIVES: To compare the effectiveness of rocuronium over suxamethonium for intubating conditions in elective surgeries.
- To compare the onset of action of both the groups.
- To assess the intubating conditions after administering both the groups.
- To compare the duration of action of both the groups.
- To compare the hemodynamic effects of both the groups.
MATERIAL & METHODS: Study Design: A Prospective Randomized comparative study. Study area: The study was conducted in the Department of Anaesthesiology, Malla Reddy Institute of Medical Sciences, Suraram, Quthbhullapur, Hyderabad, Telangana. Study Period: October 2020 to August 2021. Study population: All the patients who were undergoing the elective surgeries in the department of General Surgery during the study period. Sample size: study consisted a total of 80 cases. Sampling method: Simple Random sampling method. All patients were pre-oxygenated with 100% oxygen for 3 to 5 minutes. Pre induction heart rate and blood pressure were measured. Patient is induced with Propfol 1-2 mg/Kg-1IV. The patients received intravenous either rocuronium 0.9 mg Kg-1 or suxamethonium 1.5 mg Kg-1. Patients were ventilated with 100% O2 for 60 or 90 seconds. Intubating conditions are assessed 60 seconds after administration of the neuromuscular blocker in 20 patients receiving either agent and after 90 seconds in remaining 20 patients in each group.
Results: The duration of action among both the study groups was longer with Rocuronium and the difference between the means of duration of action was statistically significant with P value of <0.0000001.
CONCLUSION: From the present study it can be concluded that, Suxamethonium provided excellent intubating conditions over Rocuronium at 60 seconds. Intubating conditions were excellent for both the drugs at 90 sec. The duration of action was longer with Rocuronium and the difference between the means of duration of action was statistically significant.
Paper Details
PaperID:
Author's Name: Dr. Srikanth Rangu, Dr. V Praveen Kumar, Dr. Vanagondi Siva Kumar, Dr. Sachin Gangapuri
Volume: Volume 12
Issues: Volume 12
Keywords: Endotracheal intubation, Suxamethonium, Rocuronium
Year: 2022
Month: September
Pages: 63-72